NSC405020

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£149.00

SKU:: 10-1462
Physical State:: Solid
Molecular Weight:: 260.15
Purity:: 98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 7497-07-6
Immunogen:: Protease
Extra Details:: Membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14's protumorigenic activity in vivo. (IC50 > 100 uM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2. Suppresses bone erosion in a c-Fos-deficient mouse model.2 Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3