Salirasib

Size

£134.00

SKU:: 10-1461
Physical State:: Solid
Molecular Weight:: 358.54
Purity:: >98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 162520-00-5
Immunogen:: GTPase
Extra Details:: Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3. It has been investigated in the treatment of various cancers.4,5 HCC cells pretreated with salirasib were sensitized to TRAIL-induced apoptosis.6 Salirasib has also been shown to inhibit TRPA1 (EC50 = 1.3 uM).7