GSK-1702934A

Size

£158.00

SKU:: 10-1445
Physical State:: Solid
Molecular Weight:: 396.53
Purity:: 98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 924377-85-5
Immunogen:: Ion channel
Extra Details:: TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 uM and 0.44 uM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1uM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1uM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2