10-1439
ML-SA1
Size
£173.00
- SKU:
- 10-1439
- Physical State:
- Solid
- Molecular Weight:
- 362.43
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 332382-54-4
- Immunogen:
- Ion channel|Lysosome
- Extra Details:
- TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 uM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 uM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4
- Shipping Conditions:
- Ambient