10-1431
CCG-4986
Size
£158.00
- SKU:
- 10-1431
- Physical State:
- Solid
- Molecular Weight:
- 374.81
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 7134-19-2
- Immunogen:
- GAP (GTPase activating protein)
- Extra Details:
- CCG-4986 is the first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS4.1 It covalently2-3 modifies RGS4 by inhibiting its interaction with GA Alpha (IC50 = 3-5 mM) and suppressing GTPase activity1. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling.4 A novel tool for exploring the involvement of RGS4 in physiological processes.5
- Shipping Conditions:
- Ambient