10-1418
NSC697923
Size
£149.00
- SKU:
- 10-1418
- Physical State:
- Solid
- Molecular Weight:
- 267.26
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 343351-67-7
- Immunogen:
- UBC (ubiquitin conjugating enzyme)
- Extra Details:
- Selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-K KappaB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells1. Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. Acts via covalent bonding to E2 active site thiol2,3. Induces neuroblastoma cell death via activation of p53 and JNK4.
- Shipping Conditions:
- Ambient