Importazole

Size

£149.00

SKU:: 10-1412
Additional Names:: IPZ
Physical State:: Solid
Molecular Weight:: 318.43
Purity:: 97%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 662163-81-7
Immunogen:: Cytoskeleton
Extra Details:: Specifically inhibits importin-B Beta-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export1. When added to cells during mitosis it impairs the release of an importin- cargo probe and causes defects in spindle assembly. Inhibition of importin-B Beta function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-/RanGTP pathway2-4. Cell permeable