10-1361
JQ1 (+/-)
Size
£163.00
- SKU:
- 10-1361
- Physical State:
- Solid
- Molecular Weight:
- 457.00
- Purity:
- 98%
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1268524-69-1
- ABP:
- No Import Docs
- Immunogen:
- Bromodomain
- Extra Details:
- JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.
- Shipping Conditions:
- Ambient