Wiskostatin

Size

£153.00

SKU:: 10-1353
Physical State:: Solid
Molecular Weight:: 426.15
Purity:: 98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 253449-04-6
Immunogen:: Cytoskeleton
Extra Details:: A selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity1. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing N-WASP into an inactive conformation2. Inhibits PIP2-induced actin polymerization (EC50=4 uM). Perturbs agrin-elicited acetylcholine receptor clustering3. Inhibits the formation of dendritic spines and synapses in hippocampal neurons4.