10-1290
SR-1001
Size
£174.00
- SKU:
- 10-1290
- Physical State:
- Solid
- Molecular Weight:
- 477.39
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1335106-03-0
- Immunogen:
- Retinoid receptor and related|Transcription factor
- Extra Details:
- A high affinity synthetic ligand for both RORA Alpha and RORG Gammat acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity1. It inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model3. Protects against pathologic neovascularization in various mouse models of retinopathy4. Active in vivo
- Shipping Conditions:
- Ambient