10-1282
6-Thioguanine
Size
£129.00
- SKU:
- 10-1282
- Additional Names:
- 6-TG|NSC 752|NSC 76504
- Physical State:
- Solid
- Molecular Weight:
- 167.19
- Purity:
- 96%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 154-42-7
- Immunogen:
- DNA
- Extra Details:
- After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
- Shipping Conditions:
- Ambient