10-1171
A-769662
Size
£170.00
- SKU:
- 10-1171
- Physical State:
- Solid
- Molecular Weight:
- 360.39
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 844499-71-4
- Immunogen:
- Kinase
- Extra Details:
- A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the and subunits and not the AMP binding site1. EC50=0.8 M for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 M2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.
- Shipping Conditions:
- Ambient