KB-R7943 mesylate

Size

£163.00

SKU:: 10-1163
Physical State:: Solid
Molecular Weight:: 427.49
Purity:: 98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 182004-65-5
Immunogen:: Ion channel
Extra Details:: KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50's = 1.2-2.4 uM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7uM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) - Ki = 5.5 uM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 uM) and block NMDA receptors (IC50 = 13.4 uM).4