10-1162
Necrostatin-1
Size
£153.00
- SKU:
- 10-1162
- Physical State:
- Solid
- Molecular Weight:
- 259.33
- Purity:
- 98%
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 4311-88-0
- Immunogen:
- Kinase
- Extra Details:
- Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 It displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4.
- Shipping Conditions:
- Ambient