10-1037
ZM-447439
Size
£151.00
- SKU:
- 10-1037
- Physical State:
- Solid
- Molecular Weight:
- 513.59
- Purity:
- 98%
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 331771-20-1
- Immunogen:
- Cytoskeleton|Kinase
- Extra Details:
- ZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 uM, Aur C IC50 = 250 nM at physiological ATP concentrations2, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.1,2
- Shipping Conditions:
- Ambient