LFM-A13

Size

£153.00

SKU:: 10-1032
Physical State:: Solid
Molecular Weight:: 360.00
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 244240-24-2
Immunogen:: Kinase
Extra Details:: LFM-A13 is a selective inhibitor of Bruton's tyrosine kinase (BTK) - IC50's = 2.5 uM (recombinant BTK) and 17.2 uM (human BTK).1,2 It has also been shown to inhibit Polo-ilke kinase (PLK) - IC50 = 61 uM for human PLK3.3 It displayed no activity (concentrations up to 278 uM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases3.