10-1015
Ketoconazole (base)
Size
£144.00
- SKU:
- 10-1015
- Physical State:
- Solid
- Molecular Weight:
- 531.43
- Purity:
- >98%
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 65277-42-1
- Immunogen:
- Cytochrome/MDR|LO (Lipoxygenase)
- Extra Details:
- Ketoconazole is a broad spectrum antifungal agent which acts via inhibition of a cytochrome P450, CYP51A1 which is a lanosterol 14-demethylase.1 Also inhibits CYP3A and CYP1A1.2 Inhibits adrenal steroidogenesis.3 Downregulates cholesterol synthesis in drug-tolerant human lung cancer cell lines.4 Blocks the biosynthesis of leukotrienes (LT) via inhibition of 5-lipoxygenase and dose dependently inhibits LT-mediated bronchoconstriction in guinea pigs.5
- Shipping Conditions:
- Ambient