E-OSEL-M0030
QuicKey Pro Mouse VCAM-1/CD106 (Vascular cell adhesion molecule 1) ELISA Kit
Size
£120.60
Was £134.00
- SKU:
- E-OSEL-M0030
- Additional Names:
- VCAM1,CD106,INCAM-100,vascular cell adhesion molecule 1
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Reactivities:
- Mouse
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P29533
- Synonyms:
- CD106;V-CAM 1;vascular cell adhesion protein 1;Vcam;Vcam-1
- Extra Details:
- Vascular cell adhesion molecule-1 (VCAM-1, CD106) is a type I membrane glycoprotein of the immunoglobulin superfamily. Mouse VCAM-1 has two isoforms: a 110 kDa transmembrane long isoform and a 45 kDa GPI-anchored short isoform, both releasable as soluble VCAM-1. VCAM-1 is induced on vascular endothelium by inflammatory stimuli and constitutively expressed on non-vascular cells including dendritic cells, macrophages, fibroblasts, bone marrow stromal cells, and others. It mediates cell adhesion and signal transduction by binding to ligands such as integrin A Alpha4B Beta1, A Alpha4B Beta7, A AlphaDB Beta2, and A Alpha9B Beta1. VCAM-1 is critical for leukocyte recruitment to inflammation sites, T/B cell development, hematopoietic progenitor cell homing, and may facilitate melanoma metastasis. Soluble VCAM-1 promotes angiogenesis and chemotaxis. It is also associated with pathological conditions like atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, and allograft rejection.
- Shipping Conditions:
- Blue Ice