E-OSEL-M0029
QuicKey Pro Mouse LAB7-1 (B-Lymphocyte Activation Antigen B7-1) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- E-OSEL-M0029
- Additional Names:
- CD80,CD28LG,CD28LG1,BB1,B7-1 Antigen,T-lymphocyte activation antigen CD80,CTLA-4 counter-receptor B7.1
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q00609
- Synonyms:
- activation B7-1 antigen;B7 protein;B71;Cd28;Cd28l;Ly-5;Ly-53;Ly5;Ly53;MIC17;T-lymphocyte activation antigen CD80;TSA1
- Extra Details:
- B7-1 and B7-2,together with their receptors CD28 and CTLA-4,constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses.Although both CTLA-4 and CD28 can bind to the same ligands,CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.B7-1 is expressed on activated B cells,activated T cells,and macrophages.B7-2 is constitutively expressed on interdigitating dendritic cells,Langerhans cells, peripheral blood dendritic cells,memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon gamma.B7-1 and B7-2 are both members of the immunoglobulin superfamily. Mouse B7-1 is a 306 amino acid (aa) protein containing a putative 37 aa signal peptide, a 190 aa extracellular domain, a 22 aa transmembrane domain, and a 38 aa cytoplasmic domain. Mouse B7-1 and B7-2 share 28% amino acid identity. Mouse and human B7-1 share 44% amino acid identity. However, it has been observed that both human and mouse.B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.
- Shipping Conditions:
- Blue Ice