E-OSEL-M0021
QuicKey Pro Mouse EGFR (Epidermal Growth Factor Receptor) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- E-OSEL-M0021
- Additional Names:
- ErbB-1,ErbB1,ERBB
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q01279
- Synonyms:
- 9030024J15Rik;AI552599;avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;epidermal growth factor receptor;Erb;Erbb;Err;Errb1;Errp;Wa;wa-2;wa2;Wa5;waved 2
- Extra Details:
- Epidermal Growth Factor Receptor (EGFR) is a receptor tyrosine kinase that links extracellular mitogenic ligand binding to complex downstream signaling cascades. Initial ligand binding results in receptor oligomerization and autophosphorylation of multiple tyrosine residues within cytosolic domains of the the protein. These phosphorylation events stabilize the EGFR kinase activation loop and lead to the recruitment of adaptor proteins and other downstream effectors. EGFR stimulation leads to activation of RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCG Gamma-PKC and STAT signaling cascades, and constitutive activation of the receptor promotes tumorigenesis in multiple cancers.
- Shipping Conditions:
- Blue Ice