QuicKey Pro Mouse IL-18 (Interleukin 18) ELISA Kit

Size

£128.70

Was £143.00

SKU:: E-OSEL-M0020
Additional Names:: IL18,IGIF,IL-1g,IL-1F4,Interferon-gamma-inducing factor
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Mouse
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P70380
Synonyms:: IFN-gamma-inducing factor;Ig;Igif;Il-;IL-1 gamma;Il-18;interferon gamma-inducing factor;interleukin-1 gamma;interleukin-18
Extra Details:: Interleukin-18 (L-18) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-G Gamma (IFN-G Gamma) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.