QuicKey Pro Human DPP4 (Dipeptidyl Peptidase IV) ELISA Kit

Size

£120.60

Was £134.00

SKU:: E-OSEL-H0084
Additional Names:: CD26,DPPIV,ADABP,ADCP2,TP103,Adenosine Deaminase Complexing Protein 2
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Reactivities:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P27487
Synonyms:: ADABP;ADCP-2;ADCP2;adenosine deaminase complexing protein 2;CD26;dipeptidyl peptidase 4;dipeptidyl peptidase IV;dipeptidylpeptidase 4;dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2);DPP IV;DPPIV;Gly-Pro naphthylamidase;Post-proline dipeptidyl aminopeptidase IV;T-cell activation antigen CD26;TP103;Xaa-Pro-dipeptidylaminopeptidase
Extra Details:: Dipeptidyl Peptidase IV (DPPIV, also CD26 and adenosine deaminase complexing protein 2) is a serine protease that releases Xaa-Pro dipeptides from the N-terminus of oligo- and polypeptides. As a type II membrane protein, it includes a small cytoplasmic tail, a transmembrane region, and a large extracellular domain with glycosylation sites, a cysteine-rich region, and a Ser-Asp-His catalytic active site. Native DPPIV exists as a non-covalently linked homodimer on cell surfaces, with its soluble form (intact extracellular domain) present in human serum and other body fluids. DPPIV plays a key role in multiple physiological and pathological processes: it interacts with ADA and CD45 to co-stimulate the CD3/T-cell receptor complex, cleaves N-terminal Xaa-Pro-containing chemokines, altering their receptor specificity and function, degrades peptide hormones (e.g., glucagon-like peptide-1) to reduce bioactivity, with DPPIV inhibitors for type 2 diabetes in late-stage clinical trials, truncates procalcitonin (a marker for systemic bacterial/fungal infections), and interacts with HIV-1 Tat protein, whose ADA binding is inhibited by HIV envelope protein gp120.

Shipping Conditions:: Blue Ice