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QuicKey Pro Human BCAM (Basal Cell Adhesion Molecule) ELISA Kit

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E-OSEL-H0083

QuicKey Pro Human BCAM (Basal Cell Adhesion Molecule) ELISA Kit

Size

£128.70

Was £143.00

SKU:
E-OSEL-H0083
Additional Names:
CD239,BCAM,AU,LU,MSK19,Lutheran Blood Group Glycoprotein,Auberger B antigen,B-CAM cell surface glycoprotein
Application:
ELISA
Physical State:
Other Biological Fluid, Plasma, Serum
Species Reactivity:
Human
Storage Conditions:
2-8[o]C
Supplier:
Elabscience
Format:
Colorimetric method,ELISA,Sandwich
Uniprot:
P50895
Synonyms:
AU;Auberger b antigen;B-CAM cell surface glycoprotein;B-cell adhesion molecule;basal cell adhesion molecule;basal cell adhesion molecule (Lu and Au blood groups);CD239;F8/G253 antigen;LU;Lutheran antigen;Lutheran blood group glycoprotein;Lutheran blood group variant LUGA;MSK19
Extra Details:
Basal-Cell Adhesion Molecule (BCAM) and Lutheran blood group glycoprotein (LU) are two alternatively spliced variants of a single immunoglobulin superfamily (IgSF) protein that differ in the length of their cytoplasmic tails. BCAM cDNA encodes a 628 amino acid (aa) residues precursor protein with a putative 31 aa signal peptide, a 597 aa extracellular domain containing three C2 type and two V-type Ig-like domains, a 21 aa transmembrane domain, and a 19 aa cytoplasmic domain. Compared to the 40 aa cytoplasmic domain present in LU, the BCAM cytoplasmic tail lacks the putative Src homology 3 (SH3) binding site that may be involved in mediating intracellular signaling. BCAM/LU has wide tissue distribution and is expressed on erythrocytes, the endothelium of blood vessels and on the basal layer of cells in the epithelia. The expression of BCAM/LU in normal tissues is higher in fetal versus adult tissues. BCAM/LU expression is also upregulated in sickle cell disease red blood cells, in activated keratinocytes and following malignant transformation in some cell types in vivo and in vitro. BCAM/LU has been shown to be an adhesion molecule that binds laminin, a basement membrane protein involved in cell differentiation, adhesion, migration and proliferation.
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