QuicKey Pro Human CHEM (Chemerin) ELISA Kit

Size

£128.70

Was £143.00

SKU:: E-OSEL-H0066
Additional Names:: RARRES2,TIG2,Retinoic acid receptor responder protein 2,Tazarotene-induced gene 2 protein
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: Q99969
Synonyms:: chemerin;HP10433;RAR-responsive protein TIG2;retinoic acid receptor responder (tazarotene induced) 2;retinoic acid receptor responder protein 2;tazarotene-induced gene 2 protein;TIG2
Extra Details:: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Also acts as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2.Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.

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