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Mini Sample Human CXCL1 (Growth Regulated Oncogene Alpha) ELISA Kit

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E-MSEL-H0037

Mini Sample Human CXCL1 (Growth Regulated Oncogene Alpha) ELISA Kit

Size

£128.70

Was £143.00

SKU:
E-MSEL-H0037
Additional Names:
NAP3,GRO1,GRO-A,MGSA,MGSA-A,SCYB1,FSP,CINC-1
Application:
ELISA
Physical State:
Other Biological Fluid, Plasma, Serum
Species Reactivity:
Human
Storage Conditions:
2-8[o]C
Supplier:
Elabscience
Format:
Colorimetric method,ELISA,Sandwich
Uniprot:
P09341
Synonyms:
C-X-C motif chemokine 1;chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha);fibroblast secretory protein;FSP;GRO-alpha(1-73);GRO1;GRO1 oncogene (melanoma growth stimulating activity, alpha);GRO1 oncogene (melanoma growth-stimulating activity);GROa;growth-regulated alpha protein;melanoma growth stimulating activity, alpha;Melanoma growth stimulatory activity;melanoma growth stimulatory activity alpha;MGSA;MGSA alpha;MGSA-a;NAP-3;neutrophil-activating protein 3;SCYB1
Extra Details:
CXCL1/ GROA Alpha, also known as KC in mice and cinc1 in rats, is a member of the CXC chemokine family. Human CXCL1/ GROA Alpha has a total length of 107 amino acids (aa) with an estimated molecular weight of 11 kDa. The sequence homology of mouse and rat homologues to human protein was 57% and 59%, respectively. Genome-wide analysis showed that the protein encoded by the mouse Cxcl3 gene was homologous to the human CXCL1/ GROA Alpha protein. Human CXCL1/ GROA Alpha can be cleaved into three isoforms: CXCL1/ GROA Alpha (aa 4-73), CXCL1/ GROA Alpha (aa 5-73) and CXCL1/ GROA Alpha (aa 6-73), all of which are more active than full-length proteins. CXCL1/ GROA Alpha is secreted by mast cells and macrophages, so it acts as a chemical attractant of neutrophils, GRO-A Alpha plays an important role in inflammation and immune response, enhances immune defense by attracting and activating immune cells, is up-regulated in the tumor microenvironment, and is closely related to tumor growth, angiogenesis and metastasis. It can promote tumor progression by activating tumor-associated fibroblasts and endothelial cells.
Shipping Conditions:
Blue Ice