Mini Sample Human RANTES (Regulated On Activation, Normal T-Cell Expressed and Secreted) ELISA Kit

Size

£128.70

Was £143.00

SKU:: E-MSEL-H0036
Additional Names:: CCL5,SCYA5,SISd,TCP228,D17S136E
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P13501
Synonyms:: beta-chemokine RANTES;C-C motif chemokine 5;chemokine (C-C motif) ligand 5;D17S136E;eoCP;eosinophil chemotactic cytokine;RANTES;regulated upon activation, normally T-expressed, and presumably secreted;SCYA5;SIS-delta;SISd;small inducible cytokine subfamily A (Cys-Cys), member 5;Small-inducible cytokine A5;T cell-specific protein P228;T-cell specific protein p288;T-cell-specific protein RANTES;TCP228
Extra Details:: CCL5, also known as RANTES is an 8 kDa beta -chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes . CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5 . The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes . CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature .