Mini Sample Human GDF15 ( Growth Differentiation Factor 15 ) ELISA Kit

Size

£128.70

Was £143.00

SKU:: E-MSEL-H0014
Additional Names:: MIC-1,NAG-1,pTGFB,PDF,PLAB
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: Q99988
Synonyms:: GDF-15;growth/differentiation factor 15;macrophage inhibitory cytokine 1;MIC-1;MIC1;NAG-1;non-steroidal anti-inflammatory drug-activated gene-1;NRG-1;NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;PDF;PLAB;placental bone morphogenetic protein;placental TGF-beta;prostate differentiation factor;PTGF-beta;PTGFB
Extra Details:: GDF-15 is a member of the TGF-B Beta superfamily. GDF-15 is expressed as a 308 amino acids precursor that includes a signal peptide, a pro-domain, and a 112 residue mature protein. The secreted pro-domain binds to the extracellular matrix, where it can be activated by multiple enzymes such as furin (PCSK3), PCSK5, PCSK6, MMP-26, and MT1-MMP. GDF-15 is mainly expressed in placenta and prostate. Its expression is low in other tissues such as kidney, bladder, stomach, pancreas, liver, and gall bladder. GDF-15 is highly expressed in cancer cells with high levels detected in serum of cancer patients. GDF-15 has an important role in metabolic syndrome. GDF-15 transgenic mice present a lean phenotype. Furthermore, GDF-15 affects the macrophages in adipose tissue.