E-KAB-0701
Human SIRT1 Antibody Pair Set
Size
£793.80
Was £882.00
- SKU:
- E-KAB-0701
- Additional Names:
- SIR2L1,NAD-dependent deacetylase sirtuin-1
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Human
- Buffer:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Immunogen:
- SIRT1
- Formulation:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Uniprot:
- Q96EB6
- Synonyms:
- NAD-dependent protein deacetylase sirtuin-1;NAD-dependent protein deacylase sirtuin-1;regulatory protein SIR2 homolog 1;SIR2;SIR2-like protein 1;SIR2alpha;SIR2L1;sirtuin type 1
- Extra Details:
- SIRT1,the human homolog of the S. cerevisiae Sir2 protein,functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage,SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuates p53-mediated functions. When overexpressed in mouse embryo fibroblasts,SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. In mammalian cells,SIRT1 appears to control the cellular response to stress by regulating the FOXO family of forkhead transcription factors.
- Shipping Conditions:
- Blue Ice