E-KAB-0684
Mouse PDGF-BB Antibody Pair Set
Size
£793.80
Was £882.00
- SKU:
- E-KAB-0684
- Additional Names:
- c-sis,IBGC5,PDGF2,PDGF-2,PDGFB,Platelet-derived growth factor subunit B,SIS,SSV,PDGFBB,PDGF-BB
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Mouse
- Buffer:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Immunogen:
- PDGF-BB
- Formulation:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Uniprot:
- P31240
- Synonyms:
- c-sis;PDGF subunit B;PDGF-;PDGF-2;PDGF-B;platelet-derived growth factor B chain;platelet-derived growth factor beta polypeptide;platelet-derived growth factor subunit B;proto-oncogene c-Sis;Sis
- Extra Details:
- PDGF-BB is a mitogen that was initially identified as simian sarcoma viral oncogene homolog. It belongs to the Platelet-Derived Growth Factor (PDGF) family which includes five members: PDGF-AA,PDGF-BB,PDGF-AB,PDGF-CC,and PDGF-DD. PDGF-AA,AB,and BB dimers are processed intracellularly and secreted as active dimers that readily activate PDGF receptors (PDGFRs). PDGF-BB exerts its biological functions through the activation of dimeric receptors that are made up of two structurally similar protein-tyrosine kinase receptor subunits (A AlphaA Alpha-,A AlphaB Beta-,or B BetaB Beta-PDGFR). PDGF-BB induces VSMC dedifferentiation by the down regulation of contractile protein markers and the up regulation of MMP-2. In cutaneous remodeling,studies ex vivo revealed that PDGF-BB is a mitogen and chemoattractant for dermal fibroblasts. Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases,especially malignancy. Autocrine signaling is a consequence of PDGF-BB overexpression,which is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP).
- Shipping Conditions:
- Blue Ice