Mouse OxLDL Antibody Pair Set

Size

£793.80

Was £882.00

SKU:: E-KAB-0682
Additional Names:: CLEC8A,CLEC8ASLOX1,C-type lectin domain family 8 member A,hLOX-1,Lectin-like oxidized LDL receptor 1,Lectin-like oxLDL receptor 1,Lectin-type oxidized LDL receptor 1,LOX1,LOX-1,LOX1ox LDL receptor 1,LOXIN,OLR1
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Mouse
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Reactivities:: Mouse
Buffer:: Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
Immunogen:: OxLDL
Formulation:: Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
Extra Details:: Receptor that mediates the recognition,internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction,resulting in pro-inflammatory responses,pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release,monocyte adhesion and apoptosis. In addition to binding oxLDL,it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process,by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products,activated platelets,monocytes,apoptotic cells and both Gram-negative and Gram-positive bacteria.

Shipping Conditions:: Blue Ice