E-KAB-0660
Monkey PLAU/uPA Antibody Pair Set
Size
£793.80
Was £882.00
- SKU:
- E-KAB-0660
- Additional Names:
- UPA,u-PA,ATF,URK,UP-A,Urokinase,Abbokinase
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Non-human Primate
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- PLAU/uPA
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- Q9GK78
- Synonyms:
- U-PAR;UPAR;urokinase plasminogen activator receptor;urokinase plasminogen activator surface receptor
- Extra Details:
- This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active , carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA ( high molecular weight uPA ) . HMW-uPA can be further processed into LMW-uPA ( low molecular weight uPA ) by cleavage of chain A into a short chain A ( A1 ) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice