E-KAB-0609
Porcine TNF-A Alpha Antibody Pair Set
Size
£793.80
Was £882.00
- SKU:
- E-KAB-0609
- Additional Names:
- DIF,TNF-alpha,TNFA,TNFSF2
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Porcine
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Porcine
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- TNF-α
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P23563
- Synonyms:
- cachectin;TNF-a;TNF-alpha;TNFa;tumor necrosis factor;tumor necrosis factor (TNF superfamily, member 2);tumor necrosis factor alpha;tumor necrosis factor ligand superfamily member 2
- Extra Details:
- Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia , Under certain conditions it can stimulate cell proliferation and induce cell differentiation.Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.Promotes osteoclastogenesis and therefore mediates bone resorption.
- Shipping Conditions:
- Blue Ice