E-KAB-0551
Mouse IFN-G Gamma Antibody Pair Set
Size
£460.80
Was £512.00
- SKU:
- E-KAB-0551
- Additional Names:
- IFNG,IFG,IFI,Type II Interferon
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Mouse
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- IFN-γ
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P01580
- Synonyms:
- gamma interferon;If;If2f;Ifg;IFN-g;IFN-gamma;interferon 2f;interferon gamma
- Extra Details:
- Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial , antiviral , and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding , IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2 , JAK1 and STAT1 , leading to STAT1 activation , nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn , increases the quantity , quality , and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB , H/CTSH , and L/CTSL.Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development , quiescence , and differentiation.
- Shipping Conditions:
- Blue Ice