E-KAB-0549
Mouse IL-4 Antibody Pair Set
Size
£460.80
Was £512.00
- SKU:
- E-KAB-0549
- Additional Names:
- IL4,BCGF-1,BCGF1,BSF-1,BSF1
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Mouse
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- IL-4
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P07750
- Synonyms:
- B-cell growth factor 1;B-cell IgG differentiation factor;B-cell stimulatory factor 1;BSF-1;IGG1 induction factor;Il;Il-4;interleukin-4;lymphocyte stimulatory factor 1
- Extra Details:
- Cytokine secreted primarily by mast cells , T-cells , eosinophils , and basophils that plays a role in regulating antibody production , hematopoiesis and inflammation , and the development of effector T-cell responses.Induces the expression of class II MHC molecules on resting B-cells.Enhances both secretion and cell surface expression of IgE and IgG1.Regulates also the expression of the low affinity Fc receptor for IgE ( CD23 ) on both lymphocytes and monocytes.Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.In addition , plays a critical role in higher functions of the normal brain , such as memory and learning.Upon binding to IL4 , IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex , located mainly on hematopoietic cells , or with the IL13RA1 to produce the type 2 complex , which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.
- Shipping Conditions:
- Blue Ice