E-KAB-0531
Human PECAM1/CD31 Antibody Pair Set
Size
£460.80
Was £512.00
- SKU:
- E-KAB-0531
- Additional Names:
- CD31,CD31/EndoCAM,Cluster of differentiation 31,EndoCAM,GPIIA',PECA1,PECAM-1,Platelet endothelial cell adhesion molecule
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Human
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- PECAM1/CD31
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P16284
- Synonyms:
- CD31;CD31 antigen;CD31/EndoCAM;endoCAM;GPIIA';PECA1;PECAM-1;platelet endothelial cell adhesion molecule;platelet endothelial cell adhesion molecule-1
- Extra Details:
- Cell adhesion molecule which is required for leukocyte transendothelial migration ( TEM ) under most inflammatory conditions.Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment ( LBRC ) and is also essential for the LBRC membrane to be targeted around migrating leukocytes.Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions.Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils.Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells , PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes.
- Shipping Conditions:
- Blue Ice