E-KAB-0526
Human A Alpha2-M Antibody Pair Set
Size
£460.80
Was £512.00
- SKU:
- E-KAB-0526
- Additional Names:
- A Alpha2M,A2M
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Human
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- α2-M
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P01023
- Synonyms:
- A2MD;alpha-2-M;alpha-2-macroglobulin;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;CPAMD5;FWP007;S863-7
- Extra Details:
- The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases , including trypsin , thrombin and collagenase. It can also inhibit inflammatory cytokines , and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer&apos,s disease ( AD ) due to its ability to mediate the clearance and degradation of A-beta , the major component of beta-amyloid deposits. A related pseudogene , which is also located on the p arm of chromosome 12 , has been identified.
- Shipping Conditions:
- Blue Ice