Human ADAMTS5 Antibody Pair Set

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£793.80

Was £882.00

SKU:: E-KAB-0505
Additional Names:: ADAMTS5,ADAM-TS 11,ADAM-TS 5,ADAM-TS5,ADAMTS-11,ADAMTS-5,ADAMTS11,ADMP-2,ADAM metallopeptidase with thrombospondin type 1 motif 5
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Reactivities:: Human
Buffer:: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
Immunogen:: ADAMTS5
Formulation:: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
Uniprot:: Q9UNA0
Synonyms:: a disintegrin and metalloproteinase with thrombospondin motifs 11;A disintegrin and metalloproteinase with thrombospondin motifs 5;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2);ADAM-TS 11;ADAM-TS 5;ADAM-TS5;ADAMTS-11;ADAMTS-5;ADAMTS11;ADMP-2;aggrecanase-2
Extra Details:: Metalloproteinase that plays an important role in connective tissue organization , development , inflammation and cell migration. Extracellular matrix ( ECM ) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans ( CSPGs ) including ACAN , VCAN , BCAN and NCAN.Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development , including limb and cardiac morphogenesis , and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts , facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.Participates in development of brown adipose tissue and browning of white adipose tissue.Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.

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