E-KAB-0474
Human TACE/ADAM17 Antibody Pair Set
Size
£460.80
Was £512.00
- SKU:
- E-KAB-0474
- Additional Names:
- ADAM metallopeptidase domain 17,ADAM17,TACE,tumor necrosis factor-A Alpha-converting enzyme,ADAM18,CD156B,CSVP,NISBD
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Human
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- TACE/ADAM17
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P78536
- Synonyms:
- a disintegrin and metalloproteinase 17;ADAM metallopeptidase domain 18;ADAM18;cartilage snake venom-like protease;CD156B;CSVP;disintegrin and metalloproteinase domain-containing protein 17;NISBD;NISBD1;snake venom-like protease;TACE;TNF-alpha convertase;TNF-alpha convertase enzyme;TNF-alpha converting enzyme;TNF-alpha-converting enzyme;tumor necrosis factor, alpha, converting enzyme
- Extra Details:
- This gene encodes a member of the ADAM ( a disintegrin and metalloprotease domain ) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins , and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions , including fertilization , muscle development , and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha , in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates , including cell adhesion proteins , cytokine and growth factor receptors and epidermal growth factor ( EGF ) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis , rheumatoid arthritis , multiple sclerosis and Crohn's disease patients , suggesting that the encoded protein may play a role in autoimmune disease.
- Shipping Conditions:
- Blue Ice