E-KAB-0437
Human HAVCR2 Antibody Pair Set
Size
£460.80
Was £512.00
- SKU:
- E-KAB-0437
- Additional Names:
- T cell immunoglobulin and mucin domain containing protein 3,hepatitis virus cellular receptor 2,CD366
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Human
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- HAVCR2
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- Q8TDQ0
- Synonyms:
- CD366;HAVcr-2;hepatitis A virus cellular receptor 2;kidney injury molecule-3;KIM-3;SPTCL;T cell immunoglobulin mucin 3;T-cell immunoglobulin and mucin domain-containing protein 3;T-cell immunoglobulin mucin family member 3;T-cell immunoglobulin mucin receptor 3;T-cell membrane protein 3;Tim-3;TIM3;TIMD-3;TIMD3
- Extra Details:
- T cell immunoglobulin and mucin domain-3 ( TIM3 ) , also called hepatitis A virus cellular receptor 2 ( HAVCR2 ) , isa transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells , CD8 T-cells , monocytes , anddendritic cells , but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 ( PD-1 ) as twoimportant coinhibitory regulators of T cell responses , have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC.
- Shipping Conditions:
- Blue Ice