E-KAB-0428
Human HBEGF Antibody Pair Set
Size
£460.80
Was £512.00
- SKU:
- E-KAB-0428
- Additional Names:
- DTR,DTS,DTSF,Diphtheria Toxin Receptor,Diphtheria toxin receptor,HB-EGF,HEGFL,Proheparin-binding EGF-like growth factor
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Human
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- HBEGF
- Formulation:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- Q99075
- Synonyms:
- diphtheria toxin receptor (heparin-binding EGF-like growth factor);diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor);DTR;DTS;DTSF;HEGFL;heparin-binding epidermal growth factor;proheparin-binding EGF-like growth factor
- Extra Details:
- Heparin-binding EGF-like growth factor ( HB-EGF ) is a 12-16 kDa member of the epidermal growth factor ( EGF ) family. It possesses an EGF-like domain , and a heparin-binding motif. Mature HB-EGF is a soluble peptide thatarises from proteolytic processing of the transmembrane form. Human HB -EGF shows 76% and 73% aasequence identity with rat and mouse HB-EGF , respectively. It is required for normal cardiac valve formationand normal heart function , promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation , it is mitogenic for fibroblasts , but not endothelial cells. HB-EGF classified as agroup 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activityassociated with ErbB4 binding appears to be limited to non -mitogenic actions , while EGFR binding inducesboth mitogenic and non-mitogenic activity.
- Shipping Conditions:
- Blue Ice