E-KAB-0354
Mouse MIP-1A Alpha Antibody Pair Set
Size
£793.80
Was £882.00
- SKU:
- E-KAB-0354
- Additional Names:
- Mip1a,Scya3,Ccl3
- Application:
- ELISA
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Reactivities:
- Mouse
- Buffer:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Immunogen:
- MIP-1α
- Formulation:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Uniprot:
- P10855
- Synonyms:
- AI323804;C-C motif chemokine 3;CCL;G0S19-;G0S19-1;heparin-binding chemotaxis protein;L2G25B;LD78;LD78alpha;macrophage inflammatory protein 1-alpha;macrophage inflammatory protein-1alpha;Mi;MIP-;MIP-1-alpha;MIP-1alpha;MIP1;MIP1 (a);MIP1-;MIP1-(a);MIP1-alpha;Mip1a;Scy;Scya3;SIS-alpha;small-inducible cytokine A3;TY-5
- Extra Details:
- MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils.The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.
- Shipping Conditions:
- Blue Ice