Human A Alpha1-AT Antibody Pair Set

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£460.80

Was £512.00

SKU:: E-KAB-0253
Additional Names:: SERPINA1,A1A,A1AT,AAT,PI,PI1,PRO2275,alpha1AT,PRO0684,PRO2209
Application:: ELISA
Species Reactivity:: Human
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Reactivities:: Human
Buffer:: Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
Immunogen:: α1-AT
Formulation:: Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
Uniprot:: P01009
Synonyms:: A1A;A1AT;AAT;alpha-1 antitrypsin;alpha-1 protease inhibitor;alpha-1 proteinase inhibitor;alpha-1-antiproteinase;alpha-1-antitrypsin;alpha-1-antitrypsin short transcript variant 1C4;alpha-1-antitrypsin short transcript variant 1C5;alpha1AT;anti-elastase;epididymis secretory sperm binding protein;nNIF;PI;PI1;PRO2275;protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin;serine (or cysteine) proteinase inhibitor, clade A, member 1;serpin A1;serpin peptidase inhibitor clade A (alpha-1antiproteinase, antitrypsin) member 1;serpin peptidase inhibitor clade A member 1;serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Extra Details:: SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT),which is a serine protease inhibitor whose targets include elastase,plasmin,thrombin,trypsin,chymotrypsin,and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes,with smaller amountssynthesized by intestinal epithelial cells,neutrophils,pulmonary alveolar cells and macrophages. AAT is the most abundant,endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation,fibrinolysis,complement activation,apoptosis,reproduction,tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.

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