E-EL-R0888
Rat sCD14(Soluble Cluster of Differentiation 14) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- E-EL-R0888
- Additional Names:
- CD14 Antigen,Monocyte Differentiation Antigen CD14
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Rat
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q63691
- Synonyms:
- CD14 antigen;monocyte differentiation antigen CD14;myeloid cell-specific leucine-rich glycoprotein
- Extra Details:
- CD14 is a pattern recognition receptor important in innate immunity. CD14 exists in two forms, as a glycosylphosphatidylinositol-anchored protein on the surface of mononuclear cells and as a soluble protein in the blood. CD14 is shed from the surface of CD14-expressing cells, resulting in the soluble CD14 protein (sCD14). Membrane associated CD14 is a pro-inflammatory co-receptor for LPS, a characteristic constituent of the cell wall of Gram-negative bacteria. LPS interacts with LPS-binding protein (LBP) and CD14, and this complex interacts with TLR4, which subsequently induces inflammatory gene expression through NF-K KappaB and mitogen-activated protein-kinase signaling in host cells. sCD14 enables responses to LPS by cells that do not express CD14 such as endothelial cells.
- Shipping Conditions:
- Blue Ice