E-EL-M3131
Mouse IL-17C (Interleukin 17C) ELISA Kit
Size
£120.60
Was £134.00
- SKU:
- E-EL-M3131
- Additional Names:
- Interleukin-17C,Il-17c,Cytokine CX2
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Reactivities:
- Mouse
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q8K4C5
- Synonyms:
- cytokine CX2;IL-1;IL-17C;interleukin-17C
- Extra Details:
- IL-17C(Interleukin 17C) is a pro-inflammatory cytokine that plays a crucial role in epithelial innate immunity, especially against intestinal bacterial pathogens, acting in an autocrine manner. It stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense via activating the NFKB and MAPK signaling pathways. It acts synergistically with IL22, TNF and IL1B to induce antibacterial peptides. It may exert a protective effect by maintaining epithelial homeostasis after inflammatory challenges, such as intestinal inflammation in a dextran sulfate sodium-induced colitis model. It can also promote an inflammatory phenotype, e.g., in psoriatic skin. Enhanced IL17C/IL17RE signaling may increase susceptibility to autoimmune diseases like autoimmune encephalitis.
- Shipping Conditions:
- Blue Ice