E-EL-M3115
Mouse NOV (Nephroblastoma Overexpressed Gene) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- E-EL-M3115
- Additional Names:
- CCN3,IGFBP9,NOVH,IBP-9,Insulin-like growth factor-binding protein 9,Protein NOV homolog
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q64299
- Synonyms:
- C130088N23Rik;CCN;CCN family member 3;nephroblastoma overexpressed;nephroblastoma-overexpressed gene protein homolog;Nov;novH;protein NOV homolog
- Extra Details:
- NOV (CCN3) is a member of the CCN family of secreted,cysteine-rich regulatory proteins that share four conserved modules which confer distinct biological activities. These modules include an insulin-like growth factor binding domain,a von Willebrand type C domain,thrombospondin-1 domain,and a C-terminal cysteine knot domain. It is widely expressed developmentally,especially in the muscle,endothelium,nervous system,adrenal cortex,and chondrocytes. NOV (CCN3) acts through the Notch and BMP signaling pathways to modulate self-renewal and maturation of a number of cell lineages including hematopoietic,osteogenic,and chondrogenic lineages. NOV (CCN3) is also a putative ligand for integrin receptors and is tightly associated with the extracellular matrix. Its interaction with integrins alpha v beta 3 and alpha 5 beta 1 mediates endothelial cell adhesion induces chemotaxis and promotes angiogenesis. The elevated expression of NOV (CCN3) is associated with certain tumors such as Wilm's tumor and most nephroblastomas.
- Shipping Conditions:
- Blue Ice