Human SLAMF2 (Signaling Lymphocytic Activation Molecule Family, Member 2) ELISA Kit

Size

£120.60

Was £134.00

SKU:: E-EL-H6315
Additional Names:: CD48 antigen,B-lymphocyte activation marker BLAST-1,BCM1 surface antigen,Leukocyte antigen MEM-102,SLAM family member 2,SLAMF2,Signaling lymphocytic activation molecule 2
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Reactivities:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P09326
Synonyms:: B-lymphocyte activation marker BLAST-1;BCM1;BCM1 surface antigen;BLAST;BLAST1;CD48 antigen;CD48 antigen (B-cell membrane protein);hCD48;leukocyte antigen MEM-102;mCD48;MEM-102;signaling lymphocytic activation molecule 2;SLAM family member 2;SLAMF2;TCT.1
Extra Details:: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein interacts via its N-terminal immunoglobulin domain with cell surface receptors (e.g., CD244/2B4, CD2) to regulate immune cell function and activation. It participates in T-cell signaling transduction by associating with CD2, efficiently recruiting Src family protein kinase LCK and LAT to the TCR/CD3 complex, thereby promoting LCK phosphorylation and activation. Additionally, it induces phosphorylation of the cytoplasmic immunoreceptor tyrosine switch motifs (ITSMs) of CD244, initiating signaling events that drive immunological synapse formation and directed release of cytolytic granules (containing perforin and granzymes) by T-lymphocytes and NK-cells.