Human MIP-5 (Macrophage Inflammatory Protein 5) ELISA Kit

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£120.60

Was £134.00

SKU:: E-EL-H6314
Additional Names:: Chemokine CC-2 (HCC-2),Leukotactin-1 (LKN-1),MIP-1 delta,Macrophage inflammatory protein 5 (MIP-5),Mrp-2b,MIP5, NCC3,SCYA15
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Reactivities:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: Q16663
Synonyms:: C-C motif chemokine 15;chemokine (C-C motif) ligand 15;chemokine CC-2;HCC-2;HMRP-2B;leukotactin 1;Leukotactin-1;LKN-1;LKN1;macrophage inflammatory protein 5;MIP-1 delta;MIP-1D;MIP-5;MRP-2B;NCC-3;NCC3;new CC chemokine 3;SCYA15;SCYL3;small inducible cytokine subfamily A (Cys-Cys), member 15;small-inducible cytokine A15;SY15
Extra Details:: Macrophage Inflammatory Protein 5 (MIP-5), also designated as C-C motif chemokine ligand 15 (CCL15), is a member of the CC chemokine family, initially discovered by analyzing the upstream region of the CCL14 gene. Located on human chromosome 17, it is arranged in tandem with CCL14 and belongs to the NC6 beta-chemokines, featuring an extended N-terminal domain (16-20 residues) encoded by a distinct exon upstream of the first two conserved cysteines, shared with CCL6, CCL9, and CCL23. The precursor CCL15 (1-92) undergoes proteolytic processing by cathepsin G, elastase, and MT6-MMP/MMP25 to generate more active truncated forms, such as CCL15 (22-92), (24-92), (27-92), and (29-92). As a chemotactic factor, MIP-5/CCL15 primarily attracts T-cells and monocytes (not neutrophils, eosinophils, or B-cells) via binding to CC chemokine receptor 1 (CCR1), with additional binding to CCR3, and its truncated forms exhibit stronger chemoattractant activity. Clinically, it is closely associated with various diseases: elevated in renal cell carcinoma bone metastasis, pulmonary sarcoidosis bronchoalveolar lavage, severe asthma serum (reduced by omalizumab), and hepatocellular carcinoma (HCC) serum, where it promotes tumor progression via the CCL15-CCR1 axis. It is also linked to colorectal cancer and esophageal squamous cell carcinoma, highlighting its potential as a diagnostic and therapeutic target.

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