Human AGT (Angiotensinogen) ELISA Kit

Size

£128.70

Was £143.00

SKU:: E-EL-H6310
Additional Names:: ANHU,SERPINA8
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P01019
Synonyms:: alpha-1 antiproteinase, antitrypsin;angiotensin I;angiotensin II;angiotensinogen;ANHU;fetal-liver predominant transporter 1;hFLT1;pre-angiotensinogen;serine (or cysteine) proteinase inhibitor;serpin A8;serpin peptidase inhibitor, clade A, member 8;SERPINA8
Extra Details:: The protein encoded by the AGT gene is the angiotensinogen precursor, which is expressed in the liver and cleaved by reninase in response to a decrease in blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.