Human sC5b-9(Soluble Terminal Complement Complex C5b-9) ELISA Kit

Size

£128.70

Was £143.00

SKU:: E-EL-H2376
Additional Names:: C5b9,MAC,Membrane Attack Complex,TCC C5b-9,sC5b9
Application:: ELISA
Physical State:: Other Biological Fluid, Plasma, Serum
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Extra Details:: sC5b-9 (soluble C5b-9) is a terminal complement complex that is formed as a result of activation of the complement system by classical, lectin, or alternative pathways. Therefore, measuring the sC5b-9 complex can serve as an alternative marker for terminal complement activation. In the current study, we examined the possibility of soluble C5b-9 (sC5b9), the terminal complement complex, as a potential biomarker for TMA development in patients with active GVHD. Traumatic brain injury (TBI) following activation of the terminal complement pathway leads to the formation of the membrane attack complex (MACC5b-9), which induces neuronal cell death and host-mediated secondary brain injury. Serum levels of soluble MAC (sC5b-9) have not been determined in isolated TBI patients. Therefore, sC5b-9 as a biomarker in atypical hemolytic uria syndrome (aHUS), due to abnormal activation of the complement pathway at the cell surface level, can be detected by ELISA using plasma samples for sC5b-9, or as a stable MAC pore.