E-EL-H1722
Human SCCA2(Squamous Cell Carcinoma Antigen 2) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- E-EL-H1722
- Additional Names:
- LEUPIN,PI11,SCCA-2,SERPINB4,Serpin B4
- Application:
- ELISA
- Physical State:
- Other Biological Fluid, Plasma, Serum
- Species Reactivity:
- Human
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P48594
- Synonyms:
- LEUPIN;peptidase inhibitor 11;PI11;protease inhibitor (leucine-serpin);SCCA-2;SCCA1;SCCA2;SCCA2/SCCA1 fusion protein;serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4;serpin B4;serpin peptidase inhibitor, clade B (ovalbumin), member 4;squamous cell carcinoma antigen 1;squamous cell carcinoma antigen 2
- Extra Details:
- SCCA2 (squamous cell carcinoma associated antigen 2), also known as SerpinB4, is a serine protease inhibitor encoded by the SERPINB4 gene.It shares up to 92% amino acid sequence similarity with SCCA1 (squamous cell carcinoma associated antigen 1), both of which are produced primarily by different splicing forms of the same gene 1.SCCA2 is widely expressed in normal tissues, especially in squamous epithelial cells, and plays a role in inhibiting apoptosis and promoting cell division 2.Biological activity of SCCA2 SCCA2 belongs to a large family of serine trypsin inhibitors and has the activity of inhibiting a variety of proteases, including chymotrypsin and cathepsin G.This property allows SCCA2 to play an important role in the protection and repair of epithelial cells.Application of SCCA2 in tumor diagnosis SCCA2, as a tumor marker, plays an important role in the diagnosis and management of various squamous cell carcinomas.For cervical cancer in particular, an average of 55% of patients with untreated squamous cell carcinoma of the cervix have positive serum SCCA levels, a proportion that is strongly correlated with clinical stage4.
- Shipping Conditions:
- Blue Ice